Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.78 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.78 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.48 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936393 | 0.89 | PIK3CG (0.80) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL936625 | 0.88 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL936641 | 0.85 | PIK3CG (0.70) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL936846 | 0.85 | PIK3CG (0.70) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL937333 | 0.84 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL936976 | 0.84 | PIK3CG (0.78) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL936348 | 0.84 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL937620 | 0.84 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL936639 | 0.82 | PIK3CG (0.66) | PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL12909485 | 0.82 | PIK3CG (0.66) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222674-B1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2015-11-11 | — | — | EP | claimed |
| US-8865699-B2 | Amino triazoles as PI3K inhibitors | CELLZOME LTD. (GB) | 2014-10-21 | — | — | US | claimed |
| EP-2222674-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | Cellzome Limited (GB) | 2010-09-01 | — | — | EP | claimed |
| WO-2009068482-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2009-06-04 | — | — | WO | claimed |
| EP-2222674-B1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2015-11-11 | — | — | EP | disclosed |
| US-8865699-B2 | Amino triazoles as PI3K inhibitors | CELLZOME LTD. (GB) | 2014-10-21 | — | — | US | disclosed |
| EP-2222674-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | Cellzome Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009068482-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |