Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Probenecid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 known ✓ | Q4U2R8 | 1/20 | 1.00 |
| ▸ | SLC22A8 known ✓ | Q8TCC7 | 1/20 | 1.00 |
| ▸ | SLC22A11 known ✓ | Q9NSA0 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 14/20 | 1.00 |
| ▸ | CA12 | O43570 | 13/20 | 1.00 |
| ▸ | CA2 | P00918 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 1/20 | 1.00 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 1.00 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 9/20 | 0.69 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Probenecid SCHEMBL1034640 | 1.00 | CA9 (1.00) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL20636804 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL20636803 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL28892826 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL23630240 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL23391020 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL22325443 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL20636778 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL20636781 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 | |
| Probenecid SCHEMBL28422402 | 0.98 | CA9 (0.97) | CA9CA12CA2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 114476 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122084582-A | Auxiliary kit for detecting content of calcium ions in cells | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4743449-A1 | L-ARGININE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| EP-4743450-A1 | L-LYSINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| EP-4743451-A1 | TROMETHAMINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| US-20260130959-A1 | FUNGAL EXTRACTS AND FLAVOR COMBINATIONS THEREOF | Mycotechnology, Inc. (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| EP-4741492-A2 | NECROSIS INHIBITOR | Linkgevity Limited (GB) | 2026-05-13 | — | — | EP | claimed |
| CN-122005468-A | Preparation method of probenecid sodium freeze-dried powder | 安徽康正康元药业有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-0019167-A2 | Medicinal preparation for the treatment of carcinoma and process for preparing it | Limburg, Hans, Dr. (DE) | 1980-11-26 | — | — | EP | claimed |
| EP-0007025-B1 | APPARATUS FOR PREPARING SOLUTIONS OF SOLID SAMPLES FOR WET CHEMICAL ANALYSIS | Kali-Chemie Aktiengesellschaft (DE) | 1980-11-26 | — | — | EP | claimed |
| EP-0018435-A1 | Microanalytic device | Stöcker, Winfried, Dr. med. (DE) | 1980-11-12 | — | — | EP | claimed |
| WO-1980001837-A1 | PROCESS FOR SORTING COARSE-TO-FINE MATERIAL ACCORDING TO THE CHEMICAL COMPOSITION THEREOF | LUOSSAVAARA KIIRUNAVAARA AB (SE) | 1980-09-04 | — | — | WO | claimed |
| EP-0014955-A1 | Process for preparing samples of tritium or tritium and C(14) labelled materials, mainly samples of organic materials and samples of biological origin, for liquid scintillation counting, and apparatus therefor | MAGYAR TUDOMANYOS AKADEMIA KÖZP KEMIAI KUTATO INTEZET (HU) | 1980-09-03 | — | — | EP | claimed |
| EP-0014898-A1 | Test tube for analysis of samples in the clinical field, especially for urine analysis | C.A. Greiner & Söhne GmbH & Co. KG (DE) | 1980-09-03 | — | — | EP | claimed |
| EP-0009187-A1 | Method and apparatus for moisture measuring of flat samples by absorption of microwaves | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-04-02 | — | — | EP | claimed |
| EP-0007025-A1 | Apparatus for preparing solutions of solid samples for wet chemical analysis | Kali-Chemie Aktiengesellschaft (DE) | 1980-01-23 | — | — | EP | claimed |
| US-3996355-A | SACCHARIDE, VEGETABLE OIL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-12-07 | — | — | US | claimed |
| US-3959253-A | β-D-glucosyluronic acid derivatives | MERCK & CO., INC. (US) | 1976-05-25 | — | — | US | claimed |