Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.55 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.51 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004864 | 1.00 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5004866 | 1.00 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL8132799 | 0.92 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3632672 | 0.92 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL8132369 | 0.90 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL8139260 | 0.90 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5005349 | 0.90 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3626162 | 0.90 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3632747 | 0.90 | HSP90AB1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3624481 | 0.90 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146967-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | Serenex, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008130879-A2 | TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES | SERENEX, INC. (US) | 2008-10-30 | — | — | WO | disclosed |