Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.54 |
| ▸ | AKT2 | P31751 | 20/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128363 | 0.86 | AKT1 (0.41) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2367210 | 0.82 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192135 | 0.81 | AKT1 (0.55) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL29391120 | 0.81 | AKT1 (0.55) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL1738506 | 0.81 | AKT1 (0.55) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL25230276 | 0.80 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL925482 | 0.80 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17545682 | 0.80 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL927111 | 0.80 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL3131116 | 0.80 | AKT1 (0.62) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240455-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | Array Biopharma, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089453-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | ARRAY BIOPHARMA INC. (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009089453-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |