Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | PPARD | Q03181 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660421 | 0.96 | MAPT (0.36) | PTPN1MAPTALDH1A1TSHRKDM4E | |
| SCHEMBL3657976 | 0.94 | POLB (0.39) | PTPN1MAPTALDH1A1TSHRPOLB | |
| SCHEMBL3660444 | 0.93 | TP53 (0.35) | PTPN1MAPTALDH1A1POLBGABRA5 | |
| SCHEMBL2777556 | 0.90 | PTPN1 (0.43) | PTPN1MAPTALDH1A1PKMTSHR | |
| SCHEMBL3660246 | 0.88 | MEN1 (0.35) | PTPN1MAPTALDH1A1TSHRPOLB | |
| SCHEMBL3663664 | 0.87 | PTPN1 (0.41) | PTPN1MAPTALDH1A1PKMTSHR | |
| SCHEMBL2779106 | 0.85 | POLB (0.41) | PTPN1MAPTALDH1A1TSHRKDM4E | |
| SCHEMBL2776138 | 0.83 | POLB (0.47) | PTPN1MAPTALDH1A1PKMTSHR | |
| SCHEMBL2777595 | 0.82 | TP53 (0.39) | PTPN1MAPTALDH1A1PKMTSHR | |
| SCHEMBL2776688 | 0.78 | MEN1 (0.42) | PTPN1MAPTALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |