Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.70 |
| ▸ | ITK | Q08881 | 3/20 | 0.70 |
| ▸ | SYK | P43405 | 6/20 | 0.70 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221681 | 0.90 | SYK (0.70) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1222113 | 0.90 | EGFR (0.68) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1221703 | 0.90 | EGFR (0.68) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1221887 | 0.89 | EGFR (0.66) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1039968 | 0.89 | EGFR (0.71) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL12726303 | 0.88 | EGFR (0.65) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1222061 | 0.88 | EGFR (0.65) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1222074 | 0.88 | EGFR (0.65) | EGFRITKSYKPTK2AURKA | |
| Hydrochloric Acid SCHEMBL1037848 | 0.87 | EGFR (0.64) | EGFRITKSYKPTK2AURKA | |
| SCHEMBL1038012 | 0.86 | EGFR (0.63) | EGFRITKSYKPTK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234986-A2 | SULFAMIDES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080638-A2 | SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |