Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL618397 | 0.86 | CHEK1 (0.57) | CHEK1CHEK2TBK1IKBKE | |
| SCHEMBL12123026 | 0.78 | CHEK1 (0.47) | CHEK1CHEK2TBK1IKBKEEHMT2 | |
| SCHEMBL621123 | 0.72 | CHEK1 (0.64) | CHEK1CHEK2 | |
| SCHEMBL617465 | 0.71 | CHEK1 (0.66) | CHEK1CHEK2 | |
| SCHEMBL618516 | 0.69 | CHEK1 (0.62) | CHEK1CHEK2 | |
| SCHEMBL617330 | 0.68 | CHEK1 (0.61) | CHEK1CHEK2 | |
| SCHEMBL620417 | 0.67 | CHEK1 (0.60) | CHEK1CHEK2 | |
| SCHEMBL620229 | 0.66 | CHEK1 (0.62) | CHEK1CHEK2 | |
| SCHEMBL619487 | 0.65 | CHEK1 (0.61) | CHEK1CHEK2 | |
| SCHEMBL619611 | 0.64 | CHEK1 (0.59) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-A1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009044162-A1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |