Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.39 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.39 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619989 | 0.82 | CHEK1 (0.80) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL619578 | 0.80 | CHEK1 (1.00) | CHEK1CHEK2KCNH2 | |
| SCHEMBL619577 | 0.72 | CHEK1 (0.61) | CHEK1CHEK2 | |
| SCHEMBL618267 | 0.70 | CHEK1 (0.77) | CHEK1CHEK2KCNH2 | |
| SCHEMBL620023 | 0.69 | CHEK1 (0.80) | CHEK1CHEK2 | |
| SCHEMBL22944503 | 0.68 | CHEK1 (0.64) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL620971 | 0.67 | CHEK1 (0.70) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL618244 | 0.67 | CHEK1 (1.00) | CHEK1CHEK2 | |
| SCHEMBL619374 | 0.66 | CHEK1 (0.80) | CHEK1CHEK2KDR | |
| SCHEMBL618354 | 0.66 | CHEK1 (1.00) | CHEK1CHEK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-A1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009044162-A1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |