Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 15/20 | 0.47 |
| ▸ | BCL2 | P10415 | 13/20 | 0.40 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661881 | 0.90 | BCL2L1 (0.52) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL3662130 | 0.89 | BCL2L1 (0.47) | BCL2L1BCL2BCL2L2MCL1NR3C1 | |
| SCHEMBL3665619 | 0.85 | BCL2L1 (0.46) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL19145266 | 0.84 | BCL2L1 (0.66) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL3658781 | 0.80 | BCL2L1 (0.63) | BCL2L1BCL2 | |
| SCHEMBL25714995 | 0.79 | BCL2L1 (0.62) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL31570859 | 0.79 | BCL2L1 (0.62) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL3661122 | 0.78 | BCL2L1 (0.52) | BCL2L1BCL2BCL2L2CA1CA2 | |
| SCHEMBL3664204 | 0.76 | BCL2L1 (0.56) | BCL2L1BCL2 | |
| SCHEMBL26775921 | 0.75 | BCL2L1 (0.54) | BCL2L1BCL2BCL2L2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231159-A1 | METHOD OF TREATING ARTHRITIS | Abbott Laboratories (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009064938-A1 | METHOD OF TREATING ARTHRITIS | ABBOTT LABORATORIES (US) | 2009-05-22 | — | — | WO | disclosed |