Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573004 | 0.89 | MAPK14 (0.69) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL5062710 | 0.87 | MAPK14 (0.69) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL5058535 | 0.86 | MAPK14 (0.71) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL3665342 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL3665195 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL572526 | 0.85 | MAPK14 (0.69) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL3633723 | 0.85 | MAPK14 (0.73) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL572748 | 0.85 | MAPK14 (0.66) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL3665642 | 0.85 | MAPK14 (0.66) | MAPK14MAPK13RAF1ABL1KDR | |
| SCHEMBL3669158 | 0.83 | MAPK14 (0.66) | MAPK14MAPK13RAF1ABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146717-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008140895-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-11-20 | — | — | WO | disclosed |
| US-20080261961-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261961-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | KIT, BRAF, RET | MAPK14 267/4885MAPK13 183/4885RAF1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.