Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 7/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664777 | 1.00 | KDM1A (0.42) | KDM1ABACE1PDE4APDE4BPDE4C | |
| SCHEMBL3661659 | 0.90 | BACE1 (0.54) | KDM1ABACE1PDE4APDE4BPDE4C | |
| SCHEMBL30901783 | 0.82 | BCHE (0.47) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21912851 | 0.80 | BCHE (0.50) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30681524 | 0.78 | BCHE (0.48) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21912451 | 0.78 | BCHE (0.48) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17203070 | 0.78 | BCHE (0.43) | KDM1ABACE1PDE4APDE4BPDE4C | |
| SCHEMBL4775639 | 0.78 | BCHE (0.45) | KDM1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5767171 | 0.76 | BCHE (0.41) | KDM1ABACE1PDE4APDE4BPDE4C | |
| SCHEMBL3237107 | 0.75 | KDM1A (0.49) | KDM1APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240483-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089454-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |