Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15988422 | 0.99 | PARP1 (0.56) | PARP1PARP2P2RX7 | |
| Trifluoroacetic Acid SCHEMBL3078755 | 0.97 | PARP1 (0.53) | PARP1PARP2P2RX7 | |
| Trifluoroacetic Acid SCHEMBL3069595 | 0.96 | PARP1 (0.53) | PARP1PARP2P2RX7 | |
| SCHEMBL3075540 | 0.93 | PARP1 (0.54) | PARP1PARP2P2RX7 | |
| SCHEMBL3075132 | 0.93 | PARP1 (0.57) | PARP1PARP2P2RX7 | |
| SCHEMBL3073142 | 0.93 | PARP1 (0.57) | PARP1PARP2P2RX7 | |
| SCHEMBL3086938 | 0.93 | PARP1 (0.57) | PARP1PARP2P2RX7 | |
| SCHEMBL3083634 | 0.91 | PARP1 (0.48) | PARP1PARP2P2RX7 | |
| SCHEMBL3069697 | 0.91 | PARP1 (0.48) | PARP1PARP2P2RX7 | |
| Trifluoroacetic Acid SCHEMBL3083001 | 0.90 | PARP1 (0.51) | PARP1PARP2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-B1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | MSD ITALIA SRL (IT) | 2014-09-03 | — | — | EP | claimed |
| EP-2220073-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063244-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-05-22 | — | — | WO | disclosed |