Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 18/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936693 | 0.76 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL9997011 | 0.74 | PIK3CG (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL3095111 | 0.73 | PIK3CD (0.51) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL3721346 | 0.71 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL1932766 | 0.71 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL26856916 | 0.70 | PIK3CG (0.46) | PIK3CGPIK3CAPIK3CDPIK3CBIKBKE | |
| SCHEMBL1933137 | 0.69 | PIK3CG (0.52) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL12909569 | 0.68 | PIK3CG (0.59) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL614711 | 0.68 | RET (0.61) | PIK3CGPIK3CAPIK3CDPIK3CBMAP4K4 | |
| SCHEMBL9997048 | 0.68 | PIK3CG (0.47) | PIK3CGPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222674-B1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2015-11-11 | — | — | EP | claimed |
| US-8865699-B2 | Amino triazoles as PI3K inhibitors | CELLZOME LTD. (GB) | 2014-10-21 | — | — | US | claimed |
| EP-2222674-B1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2015-11-11 | — | — | EP | disclosed |
| US-8865699-B2 | Amino triazoles as PI3K inhibitors | CELLZOME LTD. (GB) | 2014-10-21 | — | — | US | disclosed |
| EP-2222674-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | Cellzome Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009068482-A1 | AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |