Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 6/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1616827 | 0.91 | DPP4 (0.43) | SIGMAR1DPP4S1PR5S1PR1 | |
| SCHEMBL1617423 | 0.89 | TACR1 (0.56) | TACR1SIGMAR1GRIN1GRIN2BDPP4 | |
| Bromide SCHEMBL3663120 | 0.80 | TACR1 (0.42) | TACR1SIGMAR1 | |
| Bromide SCHEMBL2381446 | 0.78 | TACR1 (0.61) | TACR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL731081 | 0.77 | TACR1 (0.62) | TACR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL3554063 | 0.75 | TACR1 (0.54) | TACR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL1400959 | 0.73 | TACR1 (0.61) | TACR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL29246345 | 0.72 | TACR1 (0.57) | TACR1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL6440459 | 0.71 | TACR1 (0.64) | TACR1SIGMAR1 | |
| Bromide SCHEMBL1617121 | 0.71 | SLC6A2 (0.41) | SIGMAR1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |