Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143776 | 0.82 | MAPK1 (0.34) | MAPK1HRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL25684409 | 0.74 | MAPK1 (0.37) | MAPK1KDM4EMAPTTHRBHRH3 | |
| SCHEMBL18992806 | 0.74 | MAPK1 (0.33) | MAPK1KDM4EMAPTTHRBHRH3 | |
| SCHEMBL6588171 | 0.74 | MAPK1 (0.33) | MAPK1HRH3 | |
| SCHEMBL7359958 | 0.72 | MAPK1 (0.36) | MAPK1HRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL22152561 | 0.72 | MAPK1 (0.36) | MAPK1HRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL7379626 | 0.72 | MAPK1 (0.36) | MAPK1HRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL9352211 | 0.71 | CYP2D6 (0.40) | MAPK1THRBHRH3CHRM2CHRM1 | |
| SCHEMBL9352527 | 0.71 | CYP2D6 (0.40) | MAPK1THRBHRH3CHRM2CHRM1 | |
| SCHEMBL7120805 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |