Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3069688 | 0.96 | PARP1 (0.59) | PARP1 | |
| SCHEMBL15988470 | 0.93 | PARP1 (0.59) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL3063353 | 0.90 | PARP1 (0.56) | PARP1 | |
| SCHEMBL3658008 | 0.90 | PARP1 (0.65) | PARP1 | |
| SCHEMBL15988385 | 0.88 | PARP1 (0.63) | PARP1 | |
| SCHEMBL15988351 | 0.88 | PARP1 (0.65) | PARP1 | |
| SCHEMBL15988399 | 0.88 | PARP1 (0.67) | PARP1 | |
| SCHEMBL3081524 | 0.88 | PARP1 (0.62) | PARP1 | |
| SCHEMBL15988439 | 0.87 | PARP1 (0.62) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL3074917 | 0.87 | PARP1 (0.62) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063244-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-05-22 | — | — | WO | disclosed |