Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.61 |
| ▸ | PDE2A | O00408 | 18/20 | 0.61 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970680 | 0.92 | PDE10A (0.58) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL969684 | 0.89 | PDE10A (0.75) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL968956 | 0.79 | PDE10A (0.64) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL970421 | 0.79 | PDE10A (0.71) | PDE10APDE2A | |
| SCHEMBL972371 | 0.79 | PDE10A (0.72) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL973026 | 0.77 | PDE10A (0.75) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL968812 | 0.77 | PDE10A (0.61) | PDE10APDE2APDE5APDE11APDE4A | |
| SCHEMBL969614 | 0.77 | PDE10A (1.00) | PDE10APDE2APDE5APDE11A | |
| SCHEMBL969540 | 0.76 | PDE10A (0.65) | PDE10APDE2APDE11A | |
| SCHEMBL972367 | 0.76 | PDE10A (0.60) | PDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225248-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Wyeth LLC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070584-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |