Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 10/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666128 | 0.89 | CSF1R (0.40) | KDRNTRK1RETEPHB2CSF1R | |
| SCHEMBL3666459 | 0.87 | KDR (0.54) | KDRNTRK1RETEPHB2CSF1R | |
| SCHEMBL3805641 | 0.84 | NTRK1 (0.52) | KDRNTRK1RETEPHB2CSF1R | |
| SCHEMBL5064673 | 0.83 | CSF1R (0.41) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL3806440 | 0.83 | KDR (0.43) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL3812715 | 0.82 | KDR (0.41) | KDRNTRK1RETEPHB2CSF1R | |
| SCHEMBL5067427 | 0.82 | NEK7 (0.41) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL3635080 | 0.82 | CSF1R (0.43) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL3667466 | 0.82 | CSF1R (0.43) | KDRCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL3660164 | 0.81 | CSF1R (0.42) | KDRCSF1RPDGFRAPDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146718-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131253-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080269254-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269254-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | KIT, BRAF, RET | KDR 263/4885NTRK1 163/4885RET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.