Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574404 | 0.89 | MAPK14 (0.60) | KDRNTRK1RETEPHB2MAPK14 | |
| SCHEMBL3661560 | 0.86 | MAPK14 (0.51) | KDRMAPK14MAPK13ABL1BRAF | |
| SCHEMBL3802110 | 0.86 | MAPK14 (0.52) | KDRMAPK14MAPK13ABL1BRAF | |
| SCHEMBL3664166 | 0.85 | MAPK14 (0.53) | KDRNTRK1RETEPHB2MAPK14 | |
| SCHEMBL3664223 | 0.85 | KDR (0.53) | KDRNTRK1RETEPHB2MAPK14 | |
| SCHEMBL3634646 | 0.84 | MAPK14 (0.51) | KDRMAPK14MAPK13ABL1BRAF | |
| SCHEMBL3665172 | 0.83 | MAPK14 (0.49) | KDRNTRK1MAPK14MAPK13ABL1 | |
| SCHEMBL3797307 | 0.83 | MAPK14 (0.51) | KDRMAPK14MAPK13ABL1BRAF | |
| SCHEMBL3806809 | 0.82 | MAPK14 (0.54) | KDRMAPK14MAPK13ABL1BRAF | |
| SCHEMBL5424392 | 0.82 | ABL1 (0.56) | KDRNTRK1ABL1BRAFFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146718-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131253-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080269254-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269254-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFIC DISEASES AND OTHER PROLIFERATIVE DISEASES | KIT, BRAF, RET | KDR 263/4885NTRK1 163/4885RET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.