Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513519 | 1.00 | TNF (0.61) | TNFPIK3CADYRK1ADYRK2PIK3CD | |
| SCHEMBL3515087 | 0.92 | TNF (0.69) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3515357 | 0.86 | TNF (0.65) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL12985683 | 0.84 | TNF (0.63) | TNFPIK3CADYRK1ADYRK2PIK3CD | |
| SCHEMBL3516841 | 0.84 | TNF (0.63) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3514205 | 0.83 | TNF (0.62) | TNFPIK3CADYRK1ADYRK2PIK3CD | |
| SCHEMBL3514237 | 0.83 | TNF (0.62) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3516811 | 0.83 | TNF (0.61) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3512759 | 0.82 | FYN (0.65) | TNFFYN | |
| SCHEMBL3516815 | 0.82 | TNF (0.60) | TNFPIK3CADYRK1APIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155202-A2 | 3,6-DISUBSTITUTED-IMIDAZO[1,2-B]PYRIDAZINES AND 3,5-DISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008138889-A2 | 3, 6-DISUBSTITUTED-IMIDAZO [1, 2-B] PYRIDAZINES AND 3, 5-DISUBSTITUTED PYRAZOLO[1, 5-A] PYRIMIDINES AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | claimed |