Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224323 | 1.00 | MAP4K4 (0.58) | MAP4K4PDE10ACYP8B1BTKJAK3 | |
| SCHEMBL1224777 | 0.94 | MAP4K4 (0.51) | MAP4K4PDE10ACYP8B1SYKPIM1 | |
| SCHEMBL1224773 | 0.94 | MAP4K4 (0.51) | MAP4K4PDE10ACYP8B1SYKPIM1 | |
| SCHEMBL17861337 | 0.90 | CKS1B (0.48) | MAP4K4PDE10ACYP8B1PIM1PIM3 | |
| SCHEMBL10078588 | 0.84 | CYP8B1 (0.44) | MAP4K4PDE10ACYP8B1KCNH2 | |
| SCHEMBL1222880 | 0.81 | CYP8B1 (0.48) | CYP8B1 | |
| SCHEMBL13527141 | 0.79 | CYP8B1 (0.48) | MAP4K4CYP8B1KCNH2 | |
| SCHEMBL4069637 | 0.79 | SIRT2 (0.47) | CYP8B1KCNH2 | |
| SCHEMBL2185107 | 0.79 | MAP4K4 (0.52) | MAP4K4PDE10ABTKJAK3SYK | |
| SCHEMBL2185110 | 0.79 | MAP4K4 (0.52) | MAP4K4PDE10ABTKJAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |