Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668757 | 1.00 | CYP8B1 (0.51) | CYP8B1KMT2AEHMT2EHMT1PBK | |
| SCHEMBL3667650 | 1.00 | CYP8B1 (0.51) | CYP8B1KMT2AEHMT2EHMT1PBK | |
| SCHEMBL1224249 | 0.91 | EHMT2 (0.49) | CYP8B1KMT2AEHMT2EHMT1PBK | |
| SCHEMBL3665484 | 0.90 | CYP8B1 (0.53) | CYP8B1EHMT2EHMT1PIK3CACYP2C19 | |
| SCHEMBL10078646 | 0.90 | CYP8B1 (0.53) | CYP8B1EHMT2EHMT1PIK3CACYP2C19 | |
| SCHEMBL1224565 | 0.90 | CYP8B1 (0.53) | CYP8B1EHMT2EHMT1PIK3CACYP2C19 | |
| SCHEMBL3630741 | 0.83 | EHMT2 (0.48) | CYP8B1EHMT2EHMT1PIK3CAPIK3CD | |
| SCHEMBL1222688 | 0.83 | CYP2C19 (0.54) | CYP8B1PBKPIK3CACYP2C19MAP4K4 | |
| SCHEMBL3634872 | 0.83 | CYP2C19 (0.54) | CYP8B1PBKPIK3CACYP2C19MAP4K4 | |
| SCHEMBL3636416 | 0.83 | CYP2C19 (0.54) | CYP8B1PBKPIK3CACYP2C19MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| US-8217029-B2 | Oxazolidinone antibiotics | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-10 | — | — | US | disclosed |
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |