Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661124 | 0.98 | HDAC1 (0.49) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3665044 | 0.96 | HDAC1 (0.49) | HDAC1HDAC2HDAC3NCOR1HDAC4 | |
| SCHEMBL3664645 | 0.92 | HDAC1 (0.49) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3665249 | 0.92 | HDAC1 (0.47) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3660187 | 0.92 | HDAC1 (0.46) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3664648 | 0.92 | HDAC1 (0.55) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3661501 | 0.90 | HDAC1 (0.54) | HDAC1HDAC2HDAC3NCOR1HDAC4 | |
| SCHEMBL3663934 | 0.89 | HDAC1 (0.47) | HDAC1SENP8SENP7SENP6HDAC2 | |
| SCHEMBL3663809 | 0.89 | HDAC1 (0.49) | HDAC1HDAC2HDAC3NCOR1HDAC4 | |
| SCHEMBL3660937 | 0.89 | HDAC1 (0.47) | HDAC1HDAC2HDAC3NCOR1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220066-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | Gilead Colorado, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009079391-A1 | BENZOFURAN ANILIDE HISTONE DEACETYLASE INHIBITORS | GILEAD COLORADO, INC. (US) | 2009-06-25 | — | — | WO | disclosed |