Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 7/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840734 | 0.99 | SCN5A (0.54) | SCN5ASCN9AKCNH2PIK3CAFPR2 | |
| SCHEMBL841567 | 0.82 | SCN9A (0.48) | SCN5ASCN9AKCNH2PIK3CAPIK3CD | |
| Ammonia Solution, Strong SCHEMBL3668899 | 0.82 | SCN9A (0.49) | SCN5ASCN9AKCNH2 | |
| SCHEMBL3667284 | 0.82 | KCNH2 (0.46) | SCN5ASCN9AKCNH2PIK3CAPTGES2 | |
| SCHEMBL841025 | 0.81 | SCN9A (0.49) | SCN5ASCN9AKCNH2 | |
| SCHEMBL841707 | 0.80 | SCN9A (0.44) | SCN5ASCN9AKCNH2PIK3CAPIK3CD | |
| SCHEMBL839932 | 0.80 | SCN9A (0.38) | SCN5ASCN9AKCNH2PIK3CB | |
| SCHEMBL841203 | 0.79 | SCN9A (0.46) | SCN5ASCN9AKCNH2 | |
| SCHEMBL840105 | 0.79 | SCN5A (0.52) | SCN5ASCN9AKCNH2 | |
| SCHEMBL27777594 | 0.79 | SCN5A (0.52) | SCN5ASCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |