Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | CTSS | P25774 | 10/20 | 0.64 |
| ▸ | CTSK | P43235 | 9/20 | 0.64 |
| ▸ | CTSB | P07858 | 4/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667404 | 1.00 | HDAC8 (0.64) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL3944495 | 0.93 | HDAC8 (0.72) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL9610766 | 0.93 | HDAC8 (0.72) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL19962097 | 0.91 | HDAC8 (0.68) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL29145400 | 0.90 | HDAC8 (0.58) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL29145404 | 0.90 | HDAC8 (0.58) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL23486447 | 0.90 | HDAC8 (0.61) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL28603152 | 0.90 | HDAC8 (0.61) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL3007613 | 0.89 | HDAC8 (0.63) | HDAC8CTSSCTSKCTSBCTSL | |
| SCHEMBL3007610 | 0.89 | HDAC8 (0.63) | HDAC8CTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152664-B1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-09-03 | — | — | EP | disclosed |
| US-8367709-B2 | Dipeptide analogs as coagulation factor inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-05 | — | — | US | disclosed |
| EP-2152664-A1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | Brystol-Myers Squibb Company (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008157162-A1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-24 | — | — | WO | disclosed |