Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883497 | 0.86 | KMT2A (0.40) | NR3C2POLBLARS1KMT2AMEN1 | |
| SCHEMBL10165500 | 0.86 | KMT2A (0.40) | NR3C2POLBLARS1KMT2AMEN1 | |
| SCHEMBL4883496 | 0.86 | KMT2A (0.40) | NR3C2POLBLARS1KMT2AMEN1 | |
| SCHEMBL10165431 | 0.81 | KMT2A (0.43) | NR3C2POLBKMT2AMEN1LMNA | |
| SCHEMBL4944238 | 0.81 | KMT2A (0.43) | NR3C2POLBKMT2AMEN1LMNA | |
| SCHEMBL4944245 | 0.81 | KMT2A (0.43) | NR3C2POLBKMT2AMEN1LMNA | |
| SCHEMBL10165458 | 0.74 | SMN1; SMN2 (0.46) | NR3C2POLBKMT2AMEN1LMNA | |
| SCHEMBL10165511 | 0.72 | KMT2A (0.39) | POLBKMT2AMEN1LMNAHTT | |
| SCHEMBL10165444 | 0.71 | MEN1 (0.43) | NR3C2POLBKMT2AMEN1LMNA | |
| SCHEMBL10165505 | 0.71 | POLB (0.46) | POLBKMT2AMEN1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158183-A2 | ION CHANNEL MODULATORS AND METHODS OF USE | Vertex Pharmaceuticals Incorporated (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008147797-A2 | ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-04 | — | — | WO | disclosed |