Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.46 |
| ▸ | PDE2A | O00408 | 15/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667892 | 0.89 | PDE2A (0.47) | PDE10APDE2APDE7APDE6DPDE6A | |
| SCHEMBL3655166 | 0.75 | PDE2A (0.58) | PDE10APDE2APDE7A | |
| SCHEMBL972787 | 0.75 | PDE2A (0.77) | PDE10APDE2APDE7A | |
| SCHEMBL3663728 | 0.75 | PDE10A (0.49) | PDE10APDE2APDE7APDE5APDE3A | |
| SCHEMBL972813 | 0.75 | PDE10A (0.66) | PDE10APDE2APDE7APDE11APDE6D | |
| SCHEMBL8042597 | 0.74 | PDE10A (0.49) | PDE10APDE2APDE7APDE5APDE3A | |
| SCHEMBL3653120 | 0.74 | PDE10A (0.67) | PDE10APDE2APDE7APDE5APDE3A | |
| SCHEMBL969451 | 0.74 | PDE10A (0.60) | PDE10APDE2APDE7APDE5APDE3A | |
| SCHEMBL971116 | 0.72 | PDE10A (0.61) | PDE10APDE2APDE7APDE5APDE3A | |
| SCHEMBL971026 | 0.72 | PDE10A (0.46) | PDE10APDE2APDE7APDE5APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225248-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Wyeth LLC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070584-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |