Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.47 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224071 | 1.00 | CYP2C19 (0.48) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 | |
| SCHEMBL3636416 | 0.93 | CYP2C19 (0.54) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 | |
| SCHEMBL1222688 | 0.93 | CYP2C19 (0.54) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 | |
| SCHEMBL3634872 | 0.93 | CYP2C19 (0.54) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 | |
| SCHEMBL1224035 | 0.88 | CYP2C19 (0.43) | CYP2C19PIK3CACYP8B1HRH4 | |
| SCHEMBL1222834 | 0.85 | CYP2C19 (0.46) | CYP2C19PIK3CACYP8B1ROCK2ROCK1 | |
| SCHEMBL3168429 | 0.81 | CYP8B1 (0.50) | CYP2C19PIK3CACYP8B1 | |
| SCHEMBL16986057 | 0.81 | CYP8B1 (0.41) | CYP2C19PIK3CACYP8B1 | |
| SCHEMBL1224385 | 0.81 | CYP8B1 (0.46) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 | |
| SCHEMBL3179377 | 0.81 | CYP8B1 (0.46) | CYP2C19PIK3CAPBKCYP8B1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2905283-B1 | Oxazolidinone antibiotics | ACTELION PHARMACEUTICALS LTD (CH) | 2016-12-14 | — | — | EP | disclosed |
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |