Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674683 | 0.92 | JAK2 (0.48) | JAK2KCNH2JAK3CHEK1MEN1 | |
| SCHEMBL3673550 | 0.89 | JAK2 (0.45) | JAK2KCNH2JAK3CHEK1MEN1 | |
| SCHEMBL3511797 | 0.88 | JAK2 (0.61) | JAK2KCNH2JAK3ALDH1A1GLA | |
| SCHEMBL3672735 | 0.87 | JAK2 (0.48) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3673945 | 0.83 | JAK2 (0.58) | JAK2KCNH2JAK3 | |
| SCHEMBL3672231 | 0.81 | JAK2 (0.55) | JAK2KCNH2JAK3 | |
| SCHEMBL3510009 | 0.80 | JAK2 (0.63) | JAK2KCNH2JAK3CHEK1MEN1 | |
| SCHEMBL3669584 | 0.79 | JAK2 (0.55) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3673886 | 0.79 | JAK2 (0.55) | JAK2KCNH2JAK3 | |
| SCHEMBL3671054 | 0.79 | JAK2 (0.53) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |