Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.78 |
| ▸ | JAK3 | P52333 | 2/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13116698 | 0.91 | JAK2 (0.74) | JAK2KCNH2JAK3CHEK1KDM4E | |
| SCHEMBL3512642 | 0.89 | JAK2 (0.79) | JAK2KCNH2JAK3CHEK1LCK | |
| SCHEMBL3508970 | 0.88 | JAK2 (0.77) | JAK2KCNH2JAK3CHEK1KDM4E | |
| SCHEMBL3511510 | 0.88 | JAK2 (0.77) | JAK2KCNH2JAK3CHEK1KDM4E | |
| SCHEMBL3510218 | 0.87 | JAK2 (1.00) | JAK2KCNH2JAK3CHEK1LCK | |
| SCHEMBL3510515 | 0.87 | JAK2 (0.76) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3509394 | 0.86 | JAK2 (0.75) | JAK2KCNH2JAK3CHEK1KDM4E | |
| SCHEMBL3512449 | 0.86 | JAK2 (0.89) | JAK2KCNH2JAK3CHEK1LCK | |
| SCHEMBL3509215 | 0.86 | JAK2 (0.75) | JAK2KCNH2JAK3CHEK1KDM4E | |
| SCHEMBL3514041 | 0.86 | JAK2 (0.75) | JAK2KCNH2JAK3CHEK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | claimed |
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |