Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.60 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3672482 | 0.89 | JAK2 (0.59) | JAK2JAK3KCNH2 | |
| SCHEMBL3676203 | 0.87 | JAK2 (0.46) | JAK2JAK3KCNH2 | |
| SCHEMBL3667932 | 0.86 | JAK2 (0.45) | JAK2JAK3KCNH2 | |
| SCHEMBL3672820 | 0.85 | JAK2 (0.60) | JAK2JAK3KCNH2MEN1IKBKB | |
| SCHEMBL3671860 | 0.84 | JAK2 (0.43) | JAK2JAK3KCNH2 | |
| SCHEMBL3670601 | 0.84 | JAK2 (0.43) | JAK2JAK3KCNH2 | |
| SCHEMBL1579870 | 0.83 | JAK2 (0.41) | JAK2JAK3KCNH2MEN1IKBKB | |
| SCHEMBL3671054 | 0.83 | JAK2 (0.53) | JAK2JAK3KCNH2 | |
| SCHEMBL3677158 | 0.83 | JAK2 (0.44) | JAK2JAK3KCNH2IKBKB | |
| SCHEMBL3675297 | 0.83 | JAK2 (0.44) | JAK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |