Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511575 | 0.88 | JAK2 (0.70) | JAK2KCNH2JAK3 | |
| SCHEMBL3668340 | 0.86 | JAK2 (0.45) | JAK2KCNH2JAK3 | |
| SCHEMBL3673325 | 0.84 | JAK2 (0.44) | JAK2KCNH2JAK3 | |
| SCHEMBL3669156 | 0.83 | JAK2 (0.57) | JAK2KCNH2JAK3 | |
| SCHEMBL3675141 | 0.82 | JAK2 (0.56) | JAK2KCNH2JAK3 | |
| SCHEMBL3673945 | 0.81 | JAK2 (0.58) | JAK2KCNH2JAK3 | |
| SCHEMBL3666365 | 0.81 | JAK2 (0.79) | JAK2KCNH2JAK3 | |
| SCHEMBL3669045 | 0.81 | JAK2 (0.56) | JAK2KCNH2JAK3 | |
| SCHEMBL3671490 | 0.81 | JAK2 (0.59) | JAK2KCNH2JAK3 | |
| SCHEMBL3672231 | 0.80 | JAK2 (0.55) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |