Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylhydrazine SCHEMBL3667817 | 0.88 | GRM5 (0.60) | GRM5KDM4ELMNACYP11B1 | |
| Methylhydrazine SCHEMBL3667918 | 0.87 | GRM5 (0.69) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3636026 | 0.81 | GRM5 (1.00) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3635681 | 0.81 | GRM5 (0.71) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3633851 | 0.79 | GRM5 (0.79) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3635975 | 0.76 | GRM5 (0.88) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3628685 | 0.76 | GRM5 (1.00) | GRM5GAACYP11B1HTTTP53 | |
| SCHEMBL3631813 | 0.76 | MEN1 (0.69) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3634249 | 0.75 | GRM5 (0.60) | GRM5KDM4EALDH1A1LMNATSHR | |
| SCHEMBL3633489 | 0.75 | GRM5 (0.94) | GRM5GAACYP11B1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146969-A1 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Novartis Ag (CH) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008128968-A1 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | NOVARTIS AG (CH) | 2008-10-30 | — | — | WO | disclosed |