Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673952 | 0.88 | JAK2 (0.49) | JAK2KCNH2JAK3 | |
| SCHEMBL3673644 | 0.88 | JAK2 (0.51) | JAK2KCNH2JAK3 | |
| SCHEMBL3675335 | 0.88 | JAK2 (0.47) | JAK2KCNH2JAK3PARP1PARP2 | |
| SCHEMBL3666374 | 0.87 | JAK2 (0.49) | JAK2KCNH2JAK3 | |
| SCHEMBL3511604 | 0.85 | JAK2 (0.49) | JAK2KCNH2JAK3PARP1PARP2 | |
| SCHEMBL3509783 | 0.85 | JAK2 (0.49) | JAK2KCNH2JAK3PARP1PARP2 | |
| SCHEMBL3668340 | 0.83 | JAK2 (0.45) | JAK2KCNH2JAK3ADORA3ADORA2A | |
| SCHEMBL3677381 | 0.82 | JAK2 (0.58) | JAK2KCNH2JAK3 | |
| SCHEMBL3676544 | 0.82 | JAK2 (0.49) | JAK2KCNH2JAK3NTRK1 | |
| SCHEMBL3670134 | 0.81 | JAK2 (0.50) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |