Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675294 | 0.89 | ALK (0.58) | ALKJAK2CHEK1MAPT | |
| SCHEMBL675791 | 0.83 | CHEK1 (0.55) | ALKJAK2CHEK1MAPTMAPKAPK2 | |
| SCHEMBL3666284 | 0.82 | MAPT (0.48) | ALKJAK2CHEK1MAPT | |
| SCHEMBL3724154 | 0.81 | ALK (0.47) | ALKJAK2MAPT | |
| SCHEMBL676471 | 0.81 | ALK (0.45) | ALKJAK2CHEK1MAPT | |
| SCHEMBL674333 | 0.80 | MAPT (0.53) | ALKJAK2CHEK1MAPT | |
| SCHEMBL676470 | 0.79 | ALK (0.45) | ALKJAK2 | |
| SCHEMBL15583560 | 0.78 | ALK (0.78) | ALKCDC7PIM1CDK9 | |
| SCHEMBL13464041 | 0.78 | CHEK1 (0.54) | ALKJAK2CHEK1MAPT | |
| SCHEMBL3726313 | 0.78 | ALK (0.50) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |