Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8427240 | 1.00 | — | — | |
| Acetic Acid SCHEMBL4305966 | 0.94 | — | — | |
| Acetic Acid SCHEMBL16552449 | 0.89 | — | — | |
| Acetic Acid SCHEMBL137422 | 0.89 | — | — | |
| Acetic Acid SCHEMBL11339879 | 0.89 | FFAR3 (0.78) | — | |
| Acetic Acid SCHEMBL10488853 | 0.89 | — | — | |
| Acetic Acid SCHEMBL5481671 | 0.89 | — | — | |
| Acetic Acid SCHEMBL11288986 | 0.89 | — | — | |
| Acetic Acid SCHEMBL5389203 | 0.89 | — | — | |
| Acetic Acid SCHEMBL7056890 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115385791-B | Preparation method of diacetyl tartaric acid mono-diglyceride | 常茂生物化学工程股份有限公司 | 2024-04-23 | — | — | CN | claimed |
| CN-114751852-B | Preparation method of silodosin key intermediate | 山西库邦生物医药科技有限公司 | 2023-09-15 | — | — | CN | claimed |
| CN-116574013-A | Method for preparing auxiliary fuchsin | 绍兴上虞新利化工有限公司 | 2023-08-11 | — | — | CN | claimed |
| CN-114751852-A | Preparation method of key intermediate of silodosin | 山西库邦生物医药科技有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-111423387-B | Preparation method of Giltertinib key intermediate | 苏州康纯医药科技有限公司 | 2022-03-08 | — | — | CN | claimed |
| CN-113861061-A | Amino acid amide hydrochloride without inorganic ammonium salt and synthetic method thereof | 成都市科隆化学品有限公司 | 2021-12-31 | — | — | CN | claimed |
| CN-111423387-A | Preparation method of Giltertinib key intermediate | 苏州康纯医药科技有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-104356186-B | A kind of preparation method of 3 ', 5 ' dioxies (4 pairs of methyl benzoyls) β L thymus pyrimidines | 济南尚博生物科技有限公司 | 2017-03-15 | — | — | CN | claimed |
| EP-2669266-B1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | DONG A ST CO LTD (KR) | 2016-02-24 | — | — | EP | claimed |
| CN-105315274-A | Process for synthesizing quinuclidine hydrochloride | SHANGHAI BOSHENG BIOTECHNOLOGY CO LTD | 2016-02-10 | — | — | CN | claimed |
| EP-2669266-A1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | claimed |
| EP-2669265-A2 | Improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | claimed |
| US-8598347-B2 | Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2013-12-03 | — | — | US | claimed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | claimed |
| EP-2415753-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | claimed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | claimed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | claimed |
| CN-101993444-A | Method to synthesize quinuclidine hydrochloride | SHANGHAI RC CHEMICALS CO LTD | 2011-03-30 | — | — | CN | claimed |
| EP-0087655-B1 | PROCESS FOR THE PREPARATION OF ACEMETACIN | Troponwerke GmbH & Co. KG (DE) | 1986-07-16 | — | — | EP | claimed |
| US-12006315-B2 | Intermediate useful for the synthesis of TGF-beta inhibitors and a method of preparing TGF-beta inhibitors using the same | MEDPACTO INC. (KR) | 2024-06-11 | — | — | US | disclosed |
| CN-115385791-B | Preparation method of diacetyl tartaric acid mono-diglyceride | 常茂生物化学工程股份有限公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-117567915-A | Environment-friendly coating for sand paper and production method thereof | 杭州永杰研磨材料股份有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20230303568-A1 | INTERMEDIATE USEFUL FOR THE SYNTHESIS OF TGF-BETA INHIBITORS AND A METHOD OF PREPARING TGF-BETA INHIBITORS USING THE SAME | MEDPACTO INC. (KR) | 2023-09-28 | — | — | US | disclosed |
| CN-116804009-A | Intermediate for synthesizing TGF-beta inhibitor and method for preparing TGF-beta inhibitor by using intermediate | 株式会社麦迪帕克特 | 2023-09-26 | — | — | CN | disclosed |
| CN-114751852-B | Preparation method of silodosin key intermediate | 山西库邦生物医药科技有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-116574013-A | Method for preparing auxiliary fuchsin | 绍兴上虞新利化工有限公司 | 2023-08-11 | — | — | CN | disclosed |
| US-20230125494-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCER AND INFLAMMATION | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-04-27 | — | — | US | disclosed |
| EP-4116291-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCERS AND INFLAMMATIONS | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-01-11 | — | — | EP | disclosed |
| CN-110054654-B | Synthetic method of decitabine intermediate alpha-substituted deoxyribose | 武汉百科药物开发有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-115385791-A | Preparation method of diacetyl tartaric acid ester of mono-and diglycerides | 常茂生物化学工程股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-114751852-A | Preparation method of key intermediate of silodosin | 山西库邦生物医药科技有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-109134564-B | Lactulose glycoside derivatives, preparation method and application thereof | 合肥锐思生物医药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-110698489-B | Wipatasvir intermediate, preparation method and application | 上海新礼泰药业有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-113861061-A | Amino acid amide hydrochloride without inorganic ammonium salt and synthetic method thereof | 成都市科隆化学品有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113861061-A | Amino acid amide hydrochloride without inorganic ammonium salt and synthetic method thereof | 成都市科隆化学品有限公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-113354585-A | Synthesis of novel EP4 antagonists and their use in cancer and inflammation | 湖北生物医药产业技术研究院有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-107573380-B | Wipatasvir intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2020-06-02 | — | — | CN | disclosed |
| CN-110975571-A | System and method for centralized treatment of chloroacetic acid tail gas | 莘县华祥盐化有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-107805256-B | Wipatasvir intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2020-03-31 | — | — | CN | disclosed |
| CN-107674063-B | GS5816 intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-107759577-B | GS5816 intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-107674064-B | Wipatasvir intermediate, preparation method and preparation method of Wipatasvir | 上海博志研新药物技术有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-107573355-B | Vipatasvir, intermediate and preparation method thereof | 上海博志研新药物技术有限公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-110698489-A | Wipatasvir intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-110240548-A | A kind of preparation method of Cariliprazine intermediate | 上虞京新药业有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-106478651-B | Substituted heteroaryl compound and combinations thereof and purposes | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109111451-A | Dihydropyrimidines and its application in drug | 广东东阳光药业有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-108570048-A | Substituted heteroaryl compound and combinations thereof and purposes | 广东东阳光药业有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-107805256-A | Wei Patawei intermediates and preparation method and application | 上海博志研新药物技术有限公司 | 2018-03-16 | — | — | CN | disclosed |
| CN-107759577-A | GS5816 intermediates, preparation method and application | 上海博志研新药物技术有限公司 | 2018-03-06 | — | — | CN | disclosed |
| CN-107674063-A | GS5816 intermediates and preparation method and application | 上海博志研新药物技术有限公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-107674064-A | The preparation method of Wei Patawei intermediates, preparation method and Wei Patawei | 上海博志研新药物技术有限公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-107573355-A | Wei Patawei, wherein mesosome and preparation method | 上海博志研新药物技术有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-107573380-A | Wipatasvir intermediate, preparation method and application | 上海博志研新药物技术有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-107459557-A | Left-handed Vc -2- oxygen acetyl-GRPAK, it is synthesized, activity and application | 首都医科大学 | 2017-12-12 | — | — | CN | disclosed |
| CN-107287411-A | A kind of method of arsenic in removing arsenic-containing ores | 中国科学院过程工程研究所 | 2017-10-24 | — | — | CN | disclosed |
| CN-104356186-B | A kind of preparation method of 3 ', 5 ' dioxies (4 pairs of methyl benzoyls) β L thymus pyrimidines | 济南尚博生物科技有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-106478651-A | Substituted heteroaryl compound and combinations thereof and purposes | 广东东阳光药业有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-104447394-B | Novel synthesis process of ubenimex | 成都傲飞生物化学品有限责任公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-106232587-A | Novel disubstituted 1,2, 4-triazine compounds | 田边三菱制药株式会社 | 2016-12-14 | — | — | CN | disclosed |
| CN-105968038-A | Hydrochlorides of dipeptide compounds and preparation method thereof | 湖北华世通生物医药科技有限公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-103922971-B | For the preparation of improving one's methods of the intermediate of dipeptidyl peptidase-iv inhibitor | DONG-A ST CO., LTD. (KR) | 2016-05-11 | — | — | CN | disclosed |
| EP-2669266-B1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | DONG A ST CO LTD (KR) | 2016-02-24 | — | — | EP | disclosed |
| US-9249109-B2 | Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2016-02-02 | — | — | US | disclosed |
| CN-102516184-B | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity | DONG A ST CO LTD | 2015-03-25 | — | — | CN | disclosed |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2015-01-22 | — | — | US | disclosed |
| EP-2142519-B1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | DONG A PHARM CO LTD (KR) | 2014-09-24 | — | — | EP | disclosed |
| CN-103554021-A | Indanone tetrahydroisoquinoline derivative as well as preparation method and medical application thereof | UNIV CHINA PHARMA | 2014-02-05 | — | — | CN | disclosed |
| EP-2669266-A1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| EP-2669265-A2 | Improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| US-8598347-B2 | Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2013-12-03 | — | — | US | disclosed |
| US-8198447-B2 | Fused tricyclic compound having aldose reductase inhibitory activity | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2012-06-12 | — | — | US | disclosed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| EP-2415753-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-8030315-B2 | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity | DONG-A PHARM. CO., LTD. (KR) | 2011-10-04 | — | — | US | disclosed |
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100120790-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY | DONG-A PHARM. CO., LTD (KR) | 2010-05-13 | — | — | US | disclosed |
| EP-2179999-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | National University Corporation University Of Toyama (JP) | 2010-04-28 | — | — | EP | disclosed |
| EP-2142519-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | Dong-A Pharm.Co., Ltd. (KR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008130151-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | DONG-A PHARM. CO., LTD. (KR) | 2008-10-30 | — | — | WO | disclosed |
| EP-1562908-A1 | QUINOLINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6894062-B1 | Quinoline derivatives | PFIZER INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| WO-2004043929-A1 | QUINOLINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-03-25 | — | — | US | disclosed |
| US-6100218-A | WHERE THE PHENYL IS SUBSTITUTED IN THE 3-POSITION BY A PHOSPHONO (OR OXYGEN, SULFUR AND/OR NITROGEN VARIATION, THEREOF)ALKYL GROUP; BETTER TARGETED CONTROL OF UNDESIRABLEPLANTS; DESICCANTS/DEFOLIANTS; CROPS, E.G. COTTON | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-08 | — | — | US | disclosed |
| US-5789448-A | TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; SIDE EFFECT REDUCTION | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-08-04 | — | — | US | disclosed |
| EP-0721930-A1 | BENZOYLETHYLENE DERIVATIVE | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-07-17 | — | — | EP | disclosed |
| US-5283357-A | Precipitating acid addition salt | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-02-01 | — | — | US | disclosed |
| US-5153176-A | Substituted lysine-proline-arginine peptide | NITTO BOSEKI CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| US-4863563-A | NONIONIC SURFACTANTS | OLIN CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4816461-A | 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b] indole, a process for their preparation and medicaments containing them | TROPONWERKE GMBH & CO. KG (DE) | 1989-03-28 | — | — | US | disclosed |
| US-4415495-A | ANTIARRHYTHMIC AGENTS; LOCAL ANESTHETICS | GODECKE AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| US-4410536-A | 7,8,9,10-Tetrahydrothieno[3,2-e]pyrido[4,3-b]indole compounds and their anti-depressant use | TROPONWERKE GMBH & CO. K.G. (DE) | 1983-10-18 | — | — | US | disclosed |
| EP-0035360-B1 | 5,6,8,9-TETRAHYDRO-7H-DIBENZ(D,F)AZONINE DERIVATIVES, THE PRODUCTION THEREOF AND COMPOSITIONS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1983-09-21 | — | — | EP | disclosed |
| US-4244957-A | HYPOTENSIVE AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1981-01-13 | — | — | US | disclosed |
| US-4244957-A | HYPOTENSIVE AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1981-01-13 | — | — | US | disclosed |