Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 13/20 | 0.80 |
| ▸ | MAOA | P21397 | 4/20 | 0.80 |
| ▸ | MAOB | P27338 | 4/20 | 0.80 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176723 | 0.93 | NISCH (0.77) | NISCHMAOAMAOBTAAR1ADRA2A | |
| Hydrochloric Acid SCHEMBL11259967 | 0.91 | NISCH (0.97) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL546875 | 0.89 | NISCH (1.00) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL3168522 | 0.87 | NISCH (0.73) | NISCHMAOAMAOBTAAR1ADRA2A | |
| Phenyzoline SCHEMBL3172677 | 0.86 | NISCH (1.00) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL17887925 | 0.84 | NISCH (0.68) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL3173185 | 0.84 | NISCH (0.77) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL17887929 | 0.81 | NISCH (0.62) | NISCHMAOAMAOBTAAR1ADRA2A | |
| SCHEMBL3168475 | 0.81 | NISCH (0.82) | NISCHMAOAMAOBADRA2AADRA2B | |
| SCHEMBL3172398 | 0.81 | NISCH (0.71) | NISCHMAOAMAOBTAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173720-A2 | 2-IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | claimed |
| WO-2009003868-A2 | 2 -IMIDAZOLINES HAVING A GOOD AFFINITY TO THE TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | claimed |