Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.70 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634954 | 0.82 | MAPK14 (1.00) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3635259 | 0.82 | MAPK14 (0.79) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3673322 | 0.77 | MAPK14 (0.79) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3640728 | 0.75 | MAPK14 (0.79) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3767381 | 0.75 | MAPK14 (0.65) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3762600 | 0.74 | MAPK14 (0.66) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3671305 | 0.74 | MAPK14 (0.60) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3674293 | 0.73 | MAPK14 (0.69) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3767675 | 0.73 | MAPK14 (0.78) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA | |
| SCHEMBL3669793 | 0.73 | MAPK14 (0.75) | MAPK14MAPKAPK2MAPK13RAF1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152704-A1 | PYRAZOLO-PYRIDINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | Amgen, Inc (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008137176-A1 | PYRAZOLO-PYRIDINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |