Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1428013 | 0.84 | IKBKB (0.43) | IKBKBJAK2MAPK8GAAALDH1A1 | |
| SCHEMBL1428734 | 0.81 | IKBKB (0.58) | IKBKBGAAALDH1A1MAPTHPGD | |
| SCHEMBL3677577 | 0.80 | JAK2 (0.50) | IKBKBJAK2 | |
| SCHEMBL13269976 | 0.80 | IKBKB (0.47) | IKBKBJAK2ALOX5APFEN1DGAT1 | |
| SCHEMBL1428011 | 0.79 | IKBKB (0.43) | IKBKBJAK2ALOX5APFEN1MAPT | |
| SCHEMBL3509165 | 0.78 | JAK2 (0.53) | IKBKBJAK2ALOX5APFEN1MAPK8 | |
| SCHEMBL3671507 | 0.77 | JAK2 (0.58) | JAK2 | |
| SCHEMBL3675737 | 0.75 | JAK2 (0.56) | JAK2 | |
| SCHEMBL3674591 | 0.75 | JAK2 (0.58) | JAK2 | |
| SCHEMBL3677381 | 0.75 | JAK2 (0.58) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |