Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671721 | 1.00 | KCNH2 (0.44) | KCNH2DRD2DRD3 | |
| SCHEMBL3672251 | 0.93 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL3672261 | 0.93 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL4128028 | 0.89 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL910445 | 0.84 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL910080 | 0.84 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL910443 | 0.84 | KCNH2 (0.39) | KCNH2 | |
| SCHEMBL922902 | 0.81 | KCNH2 (0.63) | KCNH2 | |
| SCHEMBL10313860 | 0.78 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL910574 | 0.77 | CYP1A2 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238138-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009087153-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |