Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 7/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984751 | 0.82 | MAP3K5 (0.43) | MAP3K5PTGDR2PIK3C3CAPN1MCL1 | |
| SCHEMBL13241039 | 0.81 | P2RY14 (0.43) | MAP3K5PTGDR2CAPN1MCL1KDM4E | |
| SCHEMBL4317149 | 0.79 | IKBKB (0.40) | PTGDR2PIK3C3MMP13 | |
| SCHEMBL13241037 | 0.78 | PTGDR2 (0.40) | MAP3K5PTGDR2PIK3C3 | |
| SCHEMBL13981531 | 0.77 | CA12 (0.48) | MAP3K5PTGDR2PIK3C3 | |
| Trifluoroacetic Acid SCHEMBL3633505 | 0.76 | MAP3K5 (0.59) | MAP3K5 | |
| SCHEMBL2987892 | 0.74 | IKBKB (0.38) | MAP3K5PTGDR2PIK3C3MMP13MMP1 | |
| SCHEMBL2987895 | 0.73 | IKBKB (0.45) | MAP3K5PTGDR2PIK3C3 | |
| SCHEMBL2980723 | 0.73 | MAP3K5 (0.52) | MAP3K5PTGDR2CAPN1MCL1 | |
| SCHEMBL13241054 | 0.69 | PTGDR2 (0.36) | MAP3K5PTGDR2PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162455-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | Glaxo Group Limited (GB) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008145688-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |