Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669360 | 0.89 | JAK2 (0.71) | JAK2KCNH2JAK3SYKCHEK1 | |
| SCHEMBL3511214 | 0.87 | JAK2 (0.59) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL3512453 | 0.87 | JAK2 (0.59) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL3510982 | 0.87 | JAK2 (0.59) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL3508820 | 0.85 | JAK2 (0.56) | JAK2KCNH2JAK3SYKCHEK1 | |
| SCHEMBL3510517 | 0.84 | JAK2 (0.61) | JAK2KCNH2JAK3SYKCHEK1 | |
| SCHEMBL3512155 | 0.84 | JAK2 (0.64) | JAK2KCNH2JAK3CHEK1IKBKE | |
| SCHEMBL3512406 | 0.83 | JAK2 (0.69) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL3511288 | 0.83 | JAK2 (0.59) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL13464968 | 0.82 | JAK2 (0.58) | JAK2KCNH2JAK3SYKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |