Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 2/20 | 0.54 |
| ▸ | CNR2 | P34972 | 2/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507146 | 0.90 | POLB (0.64) | POLBMAPTCNR1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL30951167 | 0.88 | POLB (0.63) | POLBMAPTCNR1SMN1; SMN2KMT2A | |
| SCHEMBL4968777 | 0.87 | POLB (0.65) | POLBMAPTCNR1CNR2SMN1; SMN2 | |
| SCHEMBL25199297 | 0.83 | POLB (0.57) | POLBMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8597991 | 0.82 | MAPT (0.56) | POLBMAPTCNR1SMN1; SMN2KMT2A | |
| SCHEMBL3668332 | 0.82 | POLB (0.87) | POLBMAPTSMN1; SMN2KMT2A | |
| SCHEMBL30880731 | 0.81 | NAMPT (0.50) | MAPTNAMPTSMN1; SMN2KMT2A | |
| SCHEMBL31165986 | 0.80 | MAPT (0.56) | POLBMAPTSMN1; SMN2KMT2A | |
| SCHEMBL18230251 | 0.80 | GRM4 (0.47) | POLBMAPTGRM4 | |
| SCHEMBL26451554 | 0.79 | POLB (0.53) | POLBMAPTCNR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| EP-2627649-A1 | CXCR4 RECEPTOR ANTAGONISTS | Proximagen Limited (GB) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012049277-A1 | CXCR4 RECEPTOR ANTAGONISTS | PROXIMAGEN LTD (GB) | 2012-04-19 | — | — | WO | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1957478-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007061360-A2 | NOVEL 3-BICYCLOCARBONYLAMINOPYRIDINE-2-CARBOXAMIDES OR 3-BICYCLOCARBONYLAMINOPYRAZINE-2-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | disclosed |