Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 15/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.41 |
| ▸ | PTGFR | P43088 | 2/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209812 | 0.95 | PTGER4 (0.44) | PTGER4PTGER3PTGER2ABCB11PTGFR | |
| SCHEMBL6375903 | 0.89 | PTGER4 (0.59) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3671662 | 0.89 | PTGER4 (0.59) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3671660 | 0.89 | PTGER4 (0.59) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3675003 | 0.87 | PTGER4 (0.65) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL3674999 | 0.87 | PTGER4 (0.65) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2208514 | 0.84 | PTGER4 (0.53) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2208505 | 0.84 | PTGER4 (0.53) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2212490 | 0.84 | PTGER4 (0.53) | PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL2208956 | 0.83 | PTGER4 (0.59) | PTGER4PTGER3PTGER2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513589-B1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA LTD (CA) | 2010-11-10 | — | — | EP | claimed |