⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854715 | 1.00 | — | — | |
| SCHEMBL28851839 | 0.84 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL36752 | 0.79 | — | — | |
| SCHEMBL8541354 | 0.76 | — | — | |
| SCHEMBL8541360 | 0.76 | — | — | |
| SCHEMBL4973682 | 0.74 | — | — | |
| SCHEMBL559558 | 0.73 | SMN1; SMN2 (0.59) | — | |
| SCHEMBL1801877 | 0.73 | HCAR2 (0.60) | — | |
| SCHEMBL12018827 | 0.73 | HCAR2 (0.60) | — | |
| SCHEMBL3089611 | 0.73 | HCAR2 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 682 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372755-B1 | — | — | None | — | — | US | claimed |
| EP-2356989-B1 | STABLE TABLET CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE | TORAY INDUSTRIES (JP) | 2018-02-07 | — | — | EP | claimed |
| US-9051335-B2 | Antipruritic agent for pruritus caused by multiple sclerosis | TORAY INDUSTRIES, INC. (JP) | 2015-06-09 | — | — | US | claimed |
| WO-2014210492-A1 | MOISTURE CURABLE COMPOSITION WITH STRONTIUM | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2014-12-31 | — | — | WO | claimed |
| US-8835654-B2 | Method and compositions for treating amyloid-related diseases | BHI LIMITED PARTNERSHIP (CA) | 2014-09-16 | — | — | US | claimed |
| US-8829019-B2 | Stable tablet containing 4,5-epoxymorphinan derivative | TORAY INDUSTRIES, INC. (JP) | 2014-09-09 | — | — | US | claimed |
| US-8420662-B2 | Stable solid preparation containing 4,5-epoxymorphinan derivative | TORAY INDUSTRIES, INC. (JP) | 2013-04-16 | — | — | US | claimed |
| CN-102883723-A | Therapeutic compounds and related methods of use | GALENEA CORP | 2013-01-16 | — | — | CN | claimed |
| US-20120114752-A1 | STABLE TABLET CONTAINING 4,5-EPOXYMORPHINAN DERIVATIVE | TORAY INDUSTRIES, INC. (JP) | 2012-05-10 | — | — | US | claimed |
| EP-2151241-B1 | STABLE SOLID PREPARATION COMPRISING 4,5-EPOXYMORPHINAN DERIVATIVE | TORAY INDUSTRIES (JP) | 2012-03-21 | — | — | EP | claimed |
| CN-85101029-A | The method of preparation-2-oxyindole-1-methane amide and intermediate product thereof | — | 1987-01-24 | — | — | CN | claimed |
| CN-85101028-A | Be used as the preparation of 2-oxyindole-1-methane amide that the 3-of anodyne and antiphlogistic replaces | — | 1987-01-17 | — | — | CN | claimed |
| CN-86102736-A | The preparation method and the application thereof of 6-(1-acyl group-1-methylol) penicillanic acid derivative | — | 1986-10-15 | — | — | CN | claimed |
| US-4614825-A | 7-oxabicycloheptane and 7-oxabicycloheptene compounds | E. R. SQUIBB & SONS, INC. (US) | 1986-09-30 | — | — | US | claimed |
| US-4556675-A | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds | E. R. SQUIBB & SONS, INC. (US) | 1985-12-03 | — | — | US | claimed |
| EP-0079694-A1 | 7-Oxabicyclopheptane and 7-oxabicycloheptene compounds | E.R. Squibb & Sons, Inc. (US) | 1983-05-25 | — | — | EP | claimed |
| US-4334070-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | claimed |
| EP-0035244-A2 | Cycloalka(4,5)pyrrolo(2,3-g)isoquinolines, processes and intermediates for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-09-09 | — | — | EP | claimed |
| US-4260762-A | NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | claimed |
| EP-0010661-A2 | Isoquinoline derivatives, process for their preparation, intermediates and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-05-14 | — | — | EP | claimed |