Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 19/20 | 0.74 |
| ▸ | HIPK2 | Q9H2X6 | 13/20 | 0.71 |
| ▸ | DAPK3 | O43293 | 12/20 | 0.71 |
| ▸ | CLK2 | P49760 | 12/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.71 |
| ▸ | MAP4K5 | Q9Y4K4 | 11/20 | 0.71 |
| ▸ | CDK2 | P24941 | 11/20 | 0.71 |
| ▸ | PAK4 | O96013 | 11/20 | 0.71 |
| ▸ | PRKX | P51817 | 11/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 10/20 | 0.71 |
| ▸ | MELK | Q14680 | 10/20 | 0.71 |
| ▸ | CDK7 | P50613 | 10/20 | 0.71 |
| ▸ | CDK9 | P50750 | 9/20 | 0.71 |
| ▸ | PIM1 | P11309 | 7/20 | 0.71 |
| ▸ | PRKACA | P17612 | 7/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.71 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.71 |
| ▸ | CDK8 | P49336 | 6/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284801 | 0.98 | CDC7 (0.77) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3671042 | 0.97 | CDC7 (0.78) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL4298797 | 0.90 | CDC7 (0.76) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3668102 | 0.89 | CDC7 (0.75) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3668169 | 0.88 | CDC7 (0.70) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3668190 | 0.86 | CDC7 (0.72) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL4291734 | 0.85 | CDC7 (1.00) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3673059 | 0.83 | CDC7 (0.63) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3666733 | 0.83 | CDC7 (1.00) | CDC7HIPK2DAPK3CLK2CDK5 | |
| SCHEMBL3672598 | 0.82 | CDC7 (1.00) | CDC7HIPK2DAPK3CLK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |