Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667389 | 0.78 | MAPK14 (0.79) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3671412 | 0.77 | MAPK14 (1.00) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3671305 | 0.76 | MAPK14 (0.60) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3673356 | 0.73 | MAPK14 (0.59) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3636266 | 0.72 | MAPK14 (0.82) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3632759 | 0.72 | MAPK14 (0.69) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3673594 | 0.71 | MAPK14 (0.79) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3632376 | 0.70 | MAPK14 (1.00) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3636412 | 0.70 | MAPK14 (0.77) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL23752447 | 0.69 | MAPK14 (1.00) | MAPK14MAPK13CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152704-A1 | PYRAZOLO-PYRIDINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | Amgen, Inc (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008137176-A1 | PYRAZOLO-PYRIDINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |