Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.79 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837483 | 0.90 | BTK (0.64) | BTK | |
| SCHEMBL3207086 | 0.90 | BTK (0.81) | BTKYES1FGRTECBMX | |
| SCHEMBL1726748 | 0.89 | BTK (0.74) | BTKYES1FGRTECBMX | |
| SCHEMBL3218785 | 0.89 | BTK (0.64) | BTKYES1FGRTECBMX | |
| SCHEMBL1725222 | 0.88 | BTK (1.00) | BTK | |
| SCHEMBL3207537 | 0.85 | BTK (0.73) | BTKYES1FGRTECBMX | |
| SCHEMBL3203875 | 0.84 | BTK (0.82) | BTK | |
| SCHEMBL3207651 | 0.82 | BTK (0.69) | BTKYES1FGRTECBMX | |
| SCHEMBL3211071 | 0.82 | BTK (0.69) | BTKYES1FGRTECBMX | |
| SCHEMBL1725376 | 0.81 | BTK (0.86) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242749-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. Hoffmann-La Roche AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009098144-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |