Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 16/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840415 | 0.82 | SCN9A (0.44) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL3670267 | 0.79 | KCNH2 (0.45) | SCN9ASCN5AKCNH2HTR1ASLC6A4 | |
| SCHEMBL3667613 | 0.79 | SCN5A (0.38) | SCN9ASCN5AKCNH2HTR1ASLC6A4 | |
| SCHEMBL3666273 | 0.77 | SCN5A (0.49) | SCN9ASCN5AKCNH2HTR1ASLC6A4 | |
| SCHEMBL839830 | 0.74 | SCN9A (0.52) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL840481 | 0.73 | SCN9A (0.44) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL840445 | 0.72 | SCN9A (0.55) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL840370 | 0.71 | SCN9A (0.52) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL840899 | 0.70 | SCN9A (0.51) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL840395 | 0.70 | SCN9A (0.61) | SCN9ASCN5AKCNH2SLC6A3GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |