Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.37 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11357865 | 0.88 | CHRM1 (0.39) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL16752030 | 0.88 | CHRM1 (0.39) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Lactic Acid SCHEMBL27702915 | 0.87 | TP53 (0.61) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Cadaverine Tartrate SCHEMBL537091 | 0.86 | TSHR (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Cadaverine Tartrate SCHEMBL536606 | 0.86 | TSHR (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Cadaverine Tartrate SCHEMBL10792867 | 0.86 | TSHR (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| Cadaverine Tartrate SCHEMBL536408 | 0.86 | TSHR (0.48) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL719639 | 0.84 | LCK (0.38) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL29592953 | 0.84 | FOLH1 (0.38) | TP53CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL15809468 | 0.84 | RNPEP (0.38) | TP53CHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892874-A | Double decomposition unsaturated polyol ester primer and preparation method thereof | 安徽江锐新材料有限公司 | 2020-11-06 | — | — | CN | claimed |
| CN-109846085-A | A kind of preparation method of netted polylactic acid silk screen cigarette filter tip rod | 杨成云 | 2019-06-07 | — | — | CN | claimed |
| US-7781506-B2 | Poly(vinyl alcohol) composition comprising a polyol | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-08-24 | — | — | US | claimed |
| US-20080182937-A1 | Poly(vinyl alcohol) composition comprising polyol | KURARAY CO., LTD. (JP) | 2008-07-31 | — | — | US | claimed |
| US-4675177-A | ALUMINUM-ZIRCONIUM SALTS, LACTATE ESTERS OF LOWER ALKANOLS | AMERICAN CYANAMID COMPANY (US) | 1987-06-23 | — | — | US | claimed |
| CN-111892874-A | Double decomposition unsaturated polyol ester primer and preparation method thereof | 安徽江锐新材料有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-106631779-B | Polyol esters and their use in processing halogenated vinyl polymers | 济南金昌树新材料科技有限公司 | 2020-07-14 | — | — | CN | disclosed |
| US-7781506-B2 | Poly(vinyl alcohol) composition comprising a polyol | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080182937-A1 | Poly(vinyl alcohol) composition comprising polyol | KURARAY CO., LTD. (JP) | 2008-07-31 | — | — | US | disclosed |
| US-4675177-A | ALUMINUM-ZIRCONIUM SALTS, LACTATE ESTERS OF LOWER ALKANOLS | AMERICAN CYANAMID COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| US-4132839-A | Biodegradable hydrophilic foams and method | W. R. GRACE & CO. (US) | 1979-01-02 | — | — | US | disclosed |
| US-4049592-A | Biodegradable hydrophilic foams and method | W. R. GRACE & CO. (US) | 1977-09-20 | — | — | US | disclosed |